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Mechanisms That Link Gut Dysbiosis to ME/CFS Pathogenesis A potential link between the pathophysiology of ME/CFS and alterations in the gut microbiome can be based on the communication that exists between the GI tract and the CNS [61]

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Studies demonstrate enhanced vascular health in GI tract, improved healing of colo-cutaneous fistulas, and resolution of direct stomach perforations

This means that while its origin is rooted in a natural biological component, the compound itself is a manufactured entity, which has significant implications for its classification and oversight by regulatory bodies

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Importantly, post-exercise lactate concentrations were lower for the citrulline-supplemented group, which in turn, supports the mechanism of enhancing aerobic utilization during exercise